The healing power of Sulfur
Sulfur is known as a healing mineral, a deficiency often can lead to
pain and inflammation associated with various muscles. It plays a role
in a number of biological processes. Most people don’t realize that
sulfur is present in insulin – which helps promote the utilization of
sugar.
If you want to reduce inflammation or balance your blood sugar – consider the need for sulfur.
Sulfur compounds are found in a variety of foods, such as, onions and
garlic – which appear to have anticancer properties. According to
articles that appeared in “Nutrition Science News,” by naturopathic
doctor Jill E. Stansbury – sulfur compounds inhibit tumor metabolism and
enhance immune response while helping the liver to flush out
carcinogens.
How to use nutrition to prevent cancer
Bromelain, a sulfur-rich enzyme in pineapple, has anticancer
properties (in animal studies) and is being explored for use as an
anti-carcinogenic agent for humans.
The two sulfur-containing amino acids, cysteine and methionine,
(mentioned earlier) help control the absorption of heavy metals, such as
lead. According to dermatologist Doris J. Day author of “Forget the
Facelift” says, cysteine is a key constituent of glutathione and
glutathione is the primary water-soluble antioxidant operating within
our cells – essential for detoxification.
An article published in “Planta Medica,” found that hydrogen sulfide,
a by-product of dietary sulfur compounds, offers cardiovascular
protective properties. These compounds naturally occur in onions,
garlic, beans and fruit. The authors state that research has
established a strong link between high levels of hydrogen sulfide and
cardiovascular health.
Don’t listen to the “lame-stream” media – organic food IS important!
With the introduction of the petro-chemical fertilizers, the soil has
been robbed of its sulfur content. This versatile mineral makes a
difference at every stage of life, and a deficiency can lead to many
serious health conditions.
Sulfur is an endangered element; soft water depletes our supply of
this element, and higher concentrations of chlorine and fluorine when
added to our water supply block the uptake of both oxygen and sulfur.
Sulfur is used to repair damaged cells and promote the growth of healthy
new cells by allowing the cells to transport oxygen effectively.
The best (natural) sources of sulfur are from: grass-fed beef;
pasture-raised eggs; raw cheese; organic beans, nuts, seeds, fruits and
vegetables. Keep in mind, locally-grown (organic) fruits and vegetables
– created in mineral rich soils – are always best to consume on a daily
basis.
Greater knowledge and personal experience is the best way to prevent disease
We are just beginning to appreciate the complexity of sulfur; it has
the ability to combat just about every health problem. Simply put,
sulfur will help you destroy abnormal (unhealthy) cells, while
protecting the body against environmental toxins.
As always, nature provides the formula to enhance our well-being –
all we need to do is live by its laws and enjoy life – as it’s meant to
be.
http://www.naturalhealth365.com/stop_cancer/sulfur.html
www.cellular-oxygenation.com
Tuesday, September 15, 2015
Saturday, March 28, 2015
Cure my Cancer, Stop the Virus
99.9% Pure Organic Unprocessed Sulfur Crystals
From Marine Pine trees. “A living food”
Some of the testimonies I have received:
1. Lose of
weight, naturally.
2. Softer
Skin.
3. Higher energy
levels.
4. Hot flashes
gone.
5. Hair growth
and hair color returning.
6. Stronger
nails which grow much faster.
7. Body is
producing Insulin again.
8. With the
added Oxygen to the Cells AIDS and HepC have been put into hibernation.
9. Some have
reported that Cancer has stopped its Damage and reversed.
10. Mental alertness.
11. Victims of
HepC have regenerated the Liver and stopped the Virus.
12. The list
goes on and on.
With the introduction
of chemical fertilizers in the 40’s the Sulfur cycle has all but been broken
and destroyed. By doing so the Sulfur that is essential for Oxygen “H20” to
get to the Cells has been mostly stopped and has caused havoc to our health.
Noble Price winner Dr. Otto Warburg discovered the Answer to
stop / cure Cancer. However his work, even though well documented has been
buried and not published in the medical journals.
Today’s medication is not calculated to cure, only to treat. With
drug treatment comes side effects.
Cancer by nature is anaerobic, lack of Oxygen, where more
cells keep dying and where Virus’s attach themselves too and begin their destruction
leading to death.
Back in the early 40’s and 30’s there was very little cancer
and viruses.
Today we have more cancer and viruses like never before in
history, and the death rate keeps increasing year after year.
ANSWER: OXYGEN to the cells. Natural Sulfur is the element
that carries the Oxygen to the Cells. By this Cancer cannot increase, Viruses
have no home and the immune system becomes stronger. Oxygen comes from Water.
The air we breathe only keeps the engine moving and does not bring Oxygen to
the cells. Water and Sulfur is what regenerates the Cells.
Tuesday, March 17, 2015
Imagine a nutrient more important to health than magnesium, zinc, iron, copper, sodium, iodine and, for that matter, many vitamins. Assume that it has incredibly diverse roles, boosting resistance to disease, helping regulate blood sugar, preventing aches and pains, and even holding your skin and organs together.
A mineral or nutrient without which our bodies has difficulty making the sulfur based amino acids which are necessary for the regeneration of those cells which perform all of those incredibly diverse roles.
It's a nutrient so essential for life that you would die without it. But get this: it has been all but ignored by dietitians, physicians, and researchers.
www.cellular-oxygenation.com
A mineral or nutrient without which our bodies has difficulty making the sulfur based amino acids which are necessary for the regeneration of those cells which perform all of those incredibly diverse roles.
It's a nutrient so essential for life that you would die without it. But get this: it has been all but ignored by dietitians, physicians, and researchers.
www.cellular-oxygenation.com
Thursday, March 12, 2015
Sunday, December 28, 2014
HELP!! I am looking old
So you want to look younger, have more energy, feel like you just
gained 10 years back?? Well I have GREAT News for you,, You can have
softer skin, look better, have stronger nails, more energy, stronger
hair and have your hair grow much faster. You say how is this possible?
OXYGEN to your cells.
Organic Sulfur and a good diet will do just that and much more. It does not happen over night and is a biological process but I have personally witnessed it and heard many testimonies. For myself I have NOT taken any drugs nor been sick in over 7 years. A good diet, Organic Sulfur, exercise, sunlight, and lots of good pure water is my medicine for a healthy life.
The FDA has not evaluated this information and it is just a personal statement. Results can vary and it is recommended you consult your doctor before doing any personal treatment.
www.cellular-oxygenation.com
Disclaimer:
The information presented through this Web site is presented for educational purposes only. Because there is always some risk involved when changing diet and lifestyles, the author(s) and webmaster are not responsible for any adverse effects or consequences that might result. Please do not apply the techniques or the information on this web site if you are not willing to assume the risk. If you do use the information contained on this web site without the approval of a health professional, you are prescribing for yourself, which is your constitutional right, but the author(s) and webmaster assume no responsibility. The information presented through this Web site is not medical advice, and is not given as medical advice. Nor is it intended to propose or offer to propose a cure for any disease or condition. Before starting any medical treatment, please consult a physician.
OXYGEN to your cells.
Organic Sulfur and a good diet will do just that and much more. It does not happen over night and is a biological process but I have personally witnessed it and heard many testimonies. For myself I have NOT taken any drugs nor been sick in over 7 years. A good diet, Organic Sulfur, exercise, sunlight, and lots of good pure water is my medicine for a healthy life.
The FDA has not evaluated this information and it is just a personal statement. Results can vary and it is recommended you consult your doctor before doing any personal treatment.
www.cellular-oxygenation.com
Disclaimer:
The information presented through this Web site is presented for educational purposes only. Because there is always some risk involved when changing diet and lifestyles, the author(s) and webmaster are not responsible for any adverse effects or consequences that might result. Please do not apply the techniques or the information on this web site if you are not willing to assume the risk. If you do use the information contained on this web site without the approval of a health professional, you are prescribing for yourself, which is your constitutional right, but the author(s) and webmaster assume no responsibility. The information presented through this Web site is not medical advice, and is not given as medical advice. Nor is it intended to propose or offer to propose a cure for any disease or condition. Before starting any medical treatment, please consult a physician.
Thursday, February 6, 2014
Hepatitis C Harm Reduction Project
Harm reduction is what our study is all about. And this is a request to help
find Study members with HIV, Hep C, or another viral infections. "Paradigm
shift" is forgetting that Hep C and HIV are viruses, biological entities which if
they had knowledge it would be humor at the efforts of the drug companies to
kill that which is not "alive."
Viruses whether HIV or Hep C do not seek out cells with adequate intracellular
oxygen. We are studying Organic Sulfur which enables oxygen to be transported
across the cell membrane and in doing so allowing that same membrane to
become pliable and resilient so that the viral entities can not tear into these cells.
Punching your way out of a paper bag is a similar analogy.
We have been hard pressed to enlist HIV or Hep C members but those who
have joined the study have experienced reduced viral loads. Our one success
case study died from an overdose of drugs, his liver had completely regenerated
in 15 months.
What we are suggesting is simple cellular biology, no promises or hype from
the pharmaceutical industry which has no real desire to "cure" Hep C or HIV but
only to profit from the treatment. We believe, fools that we must be, that a virus
is a virus no matter what name we give them and it must behave the way that all
viruses have since we learned of their existence.
Do a little search on viruses and oxygen, do a little search on how viruses replicate.
They do so by tearing into a leathery, stiff cell membrane which is due to anaerobic
cellular metabolism not unlike cancer and they use the DNA in that cell to replicate
more viruses to continue what should have been just a standard garbage pickup of
weak and diseased cells.
The crystals of Organic Sulfur are taken by the tablespoon for Hep C twice a day
12 to 15 grams twice a day, more has not demonstrated any adverse effects. For
HIV we believe 50 grams or 4 1/2 tablespoons of sulfur are necessary being that
the HIV virus is fond of sulfur based amino acids. Organic Sulfur has an bitter
taste initially but as one of our 92 year old Study members states, "Get over it."
Yearly cost for 200 lb Hep C study member is $200.00
Yearly cost for 150 lb HIV Study member would be $850.00 for the first 18 months
and if the viral load has decreased a similar amount that Hep C members could
suffice, that is theory for HIV but we believe that would be the case based on what
we know about intracellular oxygen and the response to most viruses.
We believe that most all US citizens are sulfur deficient thanks to the use of
chemical fertilizers and the over processing of our foods. HIV has been around
since 1860 but not until we had used chemical fertilizers did it first appear in the
West Nile Region of Africa along with Ebola and West Nile Virus.
The rise in Hep C especially among Vets did so after the use of these same
chemical fertilizers was mandated in 1954.
As Director of the Live Blood and Cellular Matrix Study we believe that both HIV
and HEP C viruses can be addressed with oral ingestion of Organic Sulfur. Viruses
avoid cells with intracellular oxygen and that is a fact of biology.
http://fourwinds10.com/NewsServer/ArticleFunctions/ArticleDetails.php?ArticleID=14542
is our preliminary Study report to give you a better idea of what we are about. No harm
to any of the current 1400 + Study members from late teens to 90+ and all to person has
benefitted in some manner from the sulfur.
No one has ever demonstrated the ability to kill a virus not even with an atomic bomb
in 1960 so when the drug companies think that they can do so with antiviral drugs possibly
they should remember that viruses are not alive, have no DNA. If forcing these "garbage
men" into dormancy is the best we can do, then I say lets do it, and the availability of
intracellular oxygen may be the answer.
Our Study is funded by the Sulfur we supply so if someone is interested it is on their
nickel, when supplied for "free" it is not taken or considered of value, we have been
doing this study since 1999 when my son was diagnosed with cancer and given a
death sentence for 2003, he is very much alive in 2007 and we believe that sulfur is
the reason.
No harm! No reason to stop any other therapy. Sulfur is the forth most abundant
of the trace minerals and we do not get any in our foods. As our report states all
disease rates in the US are now 4000% higher than they were in 1950 and that in-
cludes HIV and Hep C. Could it be the cell membrane? Could it be the lack of
intracellular oxygen? There is no harm to find out and if we are correct those Vets
with viral counts in the 30 millions could be down to under 5 million is less than
18 months.
You can continue to by hyped by the drug companies or look at an alternative
which just may be a solution, not a cure because no one has ever killed a virus
but if ones liver is allowed to regenerate and all of the viral attacks of HIV could
to halted then life could continue without the fear. And fear is the ally of the
drug companies we ally ourselves with simple cellular biology and healthy cellular
regeneration.
Patrick McGean
Study Director
The Live Blood and Cellular Matrix Study
find Study members with HIV, Hep C, or another viral infections. "Paradigm
shift" is forgetting that Hep C and HIV are viruses, biological entities which if
they had knowledge it would be humor at the efforts of the drug companies to
kill that which is not "alive."
Viruses whether HIV or Hep C do not seek out cells with adequate intracellular
oxygen. We are studying Organic Sulfur which enables oxygen to be transported
across the cell membrane and in doing so allowing that same membrane to
become pliable and resilient so that the viral entities can not tear into these cells.
Punching your way out of a paper bag is a similar analogy.
We have been hard pressed to enlist HIV or Hep C members but those who
have joined the study have experienced reduced viral loads. Our one success
case study died from an overdose of drugs, his liver had completely regenerated
in 15 months.
What we are suggesting is simple cellular biology, no promises or hype from
the pharmaceutical industry which has no real desire to "cure" Hep C or HIV but
only to profit from the treatment. We believe, fools that we must be, that a virus
is a virus no matter what name we give them and it must behave the way that all
viruses have since we learned of their existence.
Do a little search on viruses and oxygen, do a little search on how viruses replicate.
They do so by tearing into a leathery, stiff cell membrane which is due to anaerobic
cellular metabolism not unlike cancer and they use the DNA in that cell to replicate
more viruses to continue what should have been just a standard garbage pickup of
weak and diseased cells.
The crystals of Organic Sulfur are taken by the tablespoon for Hep C twice a day
12 to 15 grams twice a day, more has not demonstrated any adverse effects. For
HIV we believe 50 grams or 4 1/2 tablespoons of sulfur are necessary being that
the HIV virus is fond of sulfur based amino acids. Organic Sulfur has an bitter
taste initially but as one of our 92 year old Study members states, "Get over it."
Yearly cost for 200 lb Hep C study member is $200.00
Yearly cost for 150 lb HIV Study member would be $850.00 for the first 18 months
and if the viral load has decreased a similar amount that Hep C members could
suffice, that is theory for HIV but we believe that would be the case based on what
we know about intracellular oxygen and the response to most viruses.
We believe that most all US citizens are sulfur deficient thanks to the use of
chemical fertilizers and the over processing of our foods. HIV has been around
since 1860 but not until we had used chemical fertilizers did it first appear in the
West Nile Region of Africa along with Ebola and West Nile Virus.
The rise in Hep C especially among Vets did so after the use of these same
chemical fertilizers was mandated in 1954.
As Director of the Live Blood and Cellular Matrix Study we believe that both HIV
and HEP C viruses can be addressed with oral ingestion of Organic Sulfur. Viruses
avoid cells with intracellular oxygen and that is a fact of biology.
http://fourwinds10.com/NewsServer/ArticleFunctions/ArticleDetails.php?ArticleID=14542
is our preliminary Study report to give you a better idea of what we are about. No harm
to any of the current 1400 + Study members from late teens to 90+ and all to person has
benefitted in some manner from the sulfur.
No one has ever demonstrated the ability to kill a virus not even with an atomic bomb
in 1960 so when the drug companies think that they can do so with antiviral drugs possibly
they should remember that viruses are not alive, have no DNA. If forcing these "garbage
men" into dormancy is the best we can do, then I say lets do it, and the availability of
intracellular oxygen may be the answer.
Our Study is funded by the Sulfur we supply so if someone is interested it is on their
nickel, when supplied for "free" it is not taken or considered of value, we have been
doing this study since 1999 when my son was diagnosed with cancer and given a
death sentence for 2003, he is very much alive in 2007 and we believe that sulfur is
the reason.
No harm! No reason to stop any other therapy. Sulfur is the forth most abundant
of the trace minerals and we do not get any in our foods. As our report states all
disease rates in the US are now 4000% higher than they were in 1950 and that in-
cludes HIV and Hep C. Could it be the cell membrane? Could it be the lack of
intracellular oxygen? There is no harm to find out and if we are correct those Vets
with viral counts in the 30 millions could be down to under 5 million is less than
18 months.
You can continue to by hyped by the drug companies or look at an alternative
which just may be a solution, not a cure because no one has ever killed a virus
but if ones liver is allowed to regenerate and all of the viral attacks of HIV could
to halted then life could continue without the fear. And fear is the ally of the
drug companies we ally ourselves with simple cellular biology and healthy cellular
regeneration.
Patrick McGean
Study Director
The Live Blood and Cellular Matrix Study
Purchase Pure Crystal Organic Live Sulfur Here
Saturday, January 4, 2014
Sulfur Deficiency
Written by Stephanie Seneff, PhD
Saturday, 02 July 2011 20:37
A Possible Contributing Factor in Obesity, Heart Disease, Alzheimer’s and Chronic Fatigue
Obesity is quickly becoming the number one health issue confronting America today, and has also risen to epidemic proportions worldwide. Its spread is associated with the adoption of a Western-style diet. However, I believe that the widespread consumption of food imports produced by U.S. companies plays a crucial role in the rise in obesity worldwide. Specifically, these “fast foods” typically include heavily processed derivatives of corn, soybeans and grains, grown on highly efficient mega-farms. Furthermore, I will argue in this essay that one of the core underlying causes of obesity may be sulfur deficiency. Sulfur is the eighth most common element by mass in the human body, behind oxygen, carbon, hydrogen, nitrogen, calcium, phosphorus and potassium. The two sulfur-containing amino acids, methionine and cysteine, play essential physiological roles throughout the body. However, sulfur has been consistently overlooked by those addressing the issues of nutritional deficiencies. In fact, the National Academy of Sciences has not even assigned a minimum daily requirement (MDR) for sulfur. One consequence of sulfur’s limbo nutritional status is that it is omitted from the long list of supplements that are commonly artificially added to popular foods like cereal.
UNAPPRECIATED DEFICIENCIES
Sulfur is found in a large number of foods, and, as a consequence, it is assumed that almost any diet would meet the minimum daily requirements. Excellent sources are eggs, onions, garlic, and leafy dark green vegetables like kale and broccoli. Meats, nuts, and seafood also contain sulfur. Methionine, an essential amino acid, is found mainly in egg whites and fish. A diet high in grains like bread and cereal is likely to be deficient in sulfur. Increasingly, whole foods such as corn and soybeans are disassembled into component parts with chemical names, and then reassembled into heavily processed foods. Sulfur is lost along the way, and so is the awareness that this loss matters.
Experts have recently become aware that sulfur depletion in the soil creates a serious deficiency for plants,17 brought about in part by improved efficiency in the U.S. agricultural industry, which has steadily consolidated into highly technologized mega-farms.
It is estimated that humans obtain about ten percent of their sulfur supply from drinking water. Remarkably, people who drink soft water have an increased risk of heart disease compared to people who drink hard water.2 Many possible reasons have been suggested for why this might be true, and just about every trace metal has been considered as a possibility.3 However, I believe that the real reason may simply be that hard water is more likely to contain sulfur.
SULFUR AND OBESITY RATES
The ultimate source of sulfur is volcanic rock, mainly basalt, spewed up from the earth’s core during volcanic eruptions. It is generally believed that humans first evolved in the African rift zone, a region that would have enjoyed an abundance of sulfur due to the heavy volcanic activity there.
The three principal suppliers of sulfur to the Western nations are Greece, Italy and Japan. These three countries also enjoy low rates of heart disease and obesity and increased longevity. In the United States, Oregon and Hawaii, two states with significant volcanic activity, have among the lowest obesity rates in the country. By contrast, the highest obesity rates are found in the midwest and in southern farm country: the epicenter of the modern agricultural practices (mega-farms) that lead to sulfur depletion in the soil. Among all fifty states, Oregon has the lowest childhood obesity rates.
Hawaii’s youth are faring less well than their parents, however: while Hawaii ranks as the fifth from the bottom in obesity rates, its children aged ten through seventeen weigh in at number thirteen. As Hawaiians have recently become increasingly dependent on food imports from the mainland, they have suffered accordingly with increased obesity problems.
In her recently published book, The Jungle Effect,25 Dr. Daphne Miller devotes a full chapter to Iceland in which she struggles to answer the question of why Icelanders enjoy such remarkably low rates of depression, despite living at a northern latitude, where one would expect a high incidence of Seasonal Affective Disorder. She points out, furthermore, their excellent health record in other key areas: “When compared to North Americans, they have almost half the death rate from heart disease and diabetes, significantly less obesity, and a greater life expectancy. In fact, the average life span for Icelanders is amongst the longest in the world.” While she proposes that their high fish consumption, with associated high intake of omega-3 fats, may plausibly be the main beneficial factor, she puzzles over the fact that former Icelanders who move to Canada and also eat lots of fish do not also enjoy the same decreased rate of depression and heart disease.
In my view, the key to Icelanders’ good health lies in the string of volcanoes that make up the backbone of the island, which sits atop the mid-Atlantic ridge crest. Dr. Miller pointed out that the mass exodus to Canada was due to extensive volcanic eruptions in the late 1800s, which blanketed the highly cultivated southeast region of the country. This means, of course, that the soils today are highly enriched in sulfur. The cabbage, beets and potatoes that are staples of the Icelandic diet are likely providing far more sulfur to Icelanders than their counterparts in the American diet provide.
Source: http://www.westonaprice.org/vitamins-and-minerals/sulfur-deficiency
Where to purchase pure Organic Sulfur: www.cellular-oxygenation.com
Written by Stephanie Seneff, PhD
Saturday, 02 July 2011 20:37
A Possible Contributing Factor in Obesity, Heart Disease, Alzheimer’s and Chronic Fatigue
Obesity is quickly becoming the number one health issue confronting America today, and has also risen to epidemic proportions worldwide. Its spread is associated with the adoption of a Western-style diet. However, I believe that the widespread consumption of food imports produced by U.S. companies plays a crucial role in the rise in obesity worldwide. Specifically, these “fast foods” typically include heavily processed derivatives of corn, soybeans and grains, grown on highly efficient mega-farms. Furthermore, I will argue in this essay that one of the core underlying causes of obesity may be sulfur deficiency. Sulfur is the eighth most common element by mass in the human body, behind oxygen, carbon, hydrogen, nitrogen, calcium, phosphorus and potassium. The two sulfur-containing amino acids, methionine and cysteine, play essential physiological roles throughout the body. However, sulfur has been consistently overlooked by those addressing the issues of nutritional deficiencies. In fact, the National Academy of Sciences has not even assigned a minimum daily requirement (MDR) for sulfur. One consequence of sulfur’s limbo nutritional status is that it is omitted from the long list of supplements that are commonly artificially added to popular foods like cereal.
UNAPPRECIATED DEFICIENCIES
Sulfur is found in a large number of foods, and, as a consequence, it is assumed that almost any diet would meet the minimum daily requirements. Excellent sources are eggs, onions, garlic, and leafy dark green vegetables like kale and broccoli. Meats, nuts, and seafood also contain sulfur. Methionine, an essential amino acid, is found mainly in egg whites and fish. A diet high in grains like bread and cereal is likely to be deficient in sulfur. Increasingly, whole foods such as corn and soybeans are disassembled into component parts with chemical names, and then reassembled into heavily processed foods. Sulfur is lost along the way, and so is the awareness that this loss matters.
Experts have recently become aware that sulfur depletion in the soil creates a serious deficiency for plants,17 brought about in part by improved efficiency in the U.S. agricultural industry, which has steadily consolidated into highly technologized mega-farms.
It is estimated that humans obtain about ten percent of their sulfur supply from drinking water. Remarkably, people who drink soft water have an increased risk of heart disease compared to people who drink hard water.2 Many possible reasons have been suggested for why this might be true, and just about every trace metal has been considered as a possibility.3 However, I believe that the real reason may simply be that hard water is more likely to contain sulfur.
SULFUR AND OBESITY RATES
The ultimate source of sulfur is volcanic rock, mainly basalt, spewed up from the earth’s core during volcanic eruptions. It is generally believed that humans first evolved in the African rift zone, a region that would have enjoyed an abundance of sulfur due to the heavy volcanic activity there.
The three principal suppliers of sulfur to the Western nations are Greece, Italy and Japan. These three countries also enjoy low rates of heart disease and obesity and increased longevity. In the United States, Oregon and Hawaii, two states with significant volcanic activity, have among the lowest obesity rates in the country. By contrast, the highest obesity rates are found in the midwest and in southern farm country: the epicenter of the modern agricultural practices (mega-farms) that lead to sulfur depletion in the soil. Among all fifty states, Oregon has the lowest childhood obesity rates.
Hawaii’s youth are faring less well than their parents, however: while Hawaii ranks as the fifth from the bottom in obesity rates, its children aged ten through seventeen weigh in at number thirteen. As Hawaiians have recently become increasingly dependent on food imports from the mainland, they have suffered accordingly with increased obesity problems.
In her recently published book, The Jungle Effect,25 Dr. Daphne Miller devotes a full chapter to Iceland in which she struggles to answer the question of why Icelanders enjoy such remarkably low rates of depression, despite living at a northern latitude, where one would expect a high incidence of Seasonal Affective Disorder. She points out, furthermore, their excellent health record in other key areas: “When compared to North Americans, they have almost half the death rate from heart disease and diabetes, significantly less obesity, and a greater life expectancy. In fact, the average life span for Icelanders is amongst the longest in the world.” While she proposes that their high fish consumption, with associated high intake of omega-3 fats, may plausibly be the main beneficial factor, she puzzles over the fact that former Icelanders who move to Canada and also eat lots of fish do not also enjoy the same decreased rate of depression and heart disease.
In my view, the key to Icelanders’ good health lies in the string of volcanoes that make up the backbone of the island, which sits atop the mid-Atlantic ridge crest. Dr. Miller pointed out that the mass exodus to Canada was due to extensive volcanic eruptions in the late 1800s, which blanketed the highly cultivated southeast region of the country. This means, of course, that the soils today are highly enriched in sulfur. The cabbage, beets and potatoes that are staples of the Icelandic diet are likely providing far more sulfur to Icelanders than their counterparts in the American diet provide.
Source: http://www.westonaprice.org/vitamins-and-minerals/sulfur-deficiency
Where to purchase pure Organic Sulfur: www.cellular-oxygenation.com
Wednesday, January 1, 2014
Add Magnesium to your diet
WHAT THE EXPERTS SAY - MAGNESIUM
Many factors affect magnesium availability from
foods. One is the amount of magnesium in the soil in which the food is
grown. Much magnesium can be lost in the processing and refining of
foods and in the making of oils from the magnesium rich nuts and seeds.
Nearly 85% of magnesium is lost during the milling of flours. Soaking
and boiling foods can leach magnesium into the water, so the "pot
liquor" from cooking vegetables may be high in magnesium and other
minerals. Oxalic acid in such vegetables as spinach and chard and phytic
acid in some grains may form insoluble salts with magnesium, causing it
to be eliminated rather than absorbed. For these reasons many people get
insufficient magnesium from their diets. In fact, according to the USDA,
almost one third of the U.S. population gets under 65% of the RDA for
this mineral.
- Elison M. Haas, MD - Staying Healthy with
Nutrition
|
Magnesium is listed(1)
as an essential element in the nutritional
treatment of ADD/ADHD, Bruxism, Chronic Fatigue Syndrome, Epilepsy,
Fibromyalgia, High Blood Pressure, Muscle Cramps, Narcolepsy, Osteoporosis,
Paget's Disease, Parkinson's, Polyps, and TMJ. Very Important for Aging,
Alcoholism, Allergies, Anorexia, Anxiety Disorder,
Arteriosclerosis/Atherosclerosis, Arthritis, Asthma, Autism, Backache, Bursitis,
Cardiovascular Disease, Diabetes, Fracture, Heart Attack, Bone Spur,
Hemorrhoids, Hysterectomy Issues, Lupus, Migraine, Pancreatitis, Periodontal
Disease, PMS, Radiation Exposure, Raynaud's Disease, and Stress. Important in Alzheimer's Disease, Bladder
Infection, Bulimia, Candidiasis, Circulatory Problems, Cirrhosis of the Liver,
Cold Sores, Drug Addiction, Edema, Growth Problems, Hearing Loss, Hepatitis,
Herpes, Hypoglycemia, Incontinence, Insomnia, Malabsorption, Menopausal
Problems, Motion Sickness, Multiple Sclerosis, Shingles, Thrombophlebitis,
Tooth Decay, Wilson's Disease & Helpful for Adrenal Disorders, Age
Spots, Bedsores, Bronchitis, Bruising,
Burns, Constipation, Crohn's Disease, Depression, Diarrhea, Emphysema,
Endometriosis, Gangrene, Rubella, Glaucoma, Gout, Hay Fever, Headache,
Heartburn/GERD, Hemophilia, Irritable Bowel Syndrome, Kidney Disease, Lactose
Intolerance, Bipolar Disorder, Measles, Mononucleosis, Nail Problems,
Prostatitis, Psoriasis, Rheumatic Fever, Schizophrenia, Sunburn, Ulcerative
Colitis, Vaginitis, Varicose Veins, Vertigo, and Wrinkles.
Friday, December 27, 2013
Cancer Killed by Oxygen
THERE ARE MANY CAUSES OF CANCER, BUT THERE IS ONLY ONE PRIME CAUSE . . . THE LACK OF OXYGEN AT THE CELLULAR LEVEL.
The Prime Cause of Cancer
In order to understand the dramatic effect of increased oxygenation on cancer (and all anaerobic diseases) it is important to explain the conditions (and the only conditions) which allow cancer cells to not only survive but multiply and flourish. In order to do this an explanation of the metabolism of healthy and unhealthy cells must be explained- or in this case non-cancerous and cancerous cells.
A normal healthy cell burns oxygen and glucose (blood sugar) for energy and releases carbon dioxide and. This healthy cell is functioning aerobically- in the presence of sufficient oxygen. No anaerobic (cancer, Epstein Barr, herpes, mono, genital warts, etc.) can flourish, replicate or even survive in this oxygen rich environment.
An unhealthy or diseased cell is lacking sufficient oxygen but will still produce energy by burning mainly. This is very inefficient and a severe drain on the body. This energy burning process (sugar fermentation) releases mainly lactic acid and carbon monoxide instead of carbon dioxide. This cell is functioning anaerobically- with no oxygen present. Cancer, viral diseases, etc. flourish in this environment-little or no oxygen (and low PH).
Anaerobic cells must work harder than aerobic cells to produce energy from the glucose they metabolize.
Therefore, anaerobic cells burn much more glucose to produce the same amount of energy as aerobic. Cancer cells exhibit this anaerobic mode of metabolism- lack of oxygen, high glucose consumption, carbon monoxide and high lactic acid production. Cancer cells thrive in this high sugar-low oxygen environment but cannot exist in the opposite condition of high oxygen-low sugar mode of healthy cells.
Dr. Otto Warburg, whose name has been bandied about so often that his significance has been unjustifiably minimized, was a biochemist in cancer research. He won the Nobel Prize in Medicine for proving that a cancer cell cannot exist in an oxidizing, healthy cell. Dr. Waburgh was the director of the Max Planck Institute for Cell Physiology in Germany. In "The Prime Cause and Prevention of Cancer" 1967,
Dr. Warburg proposed that normalizing the metabolism of cancer cells was the key to effective treatment cancer and the means to accomplish this was to increase the oxygen content of the cells. Dr.Warburg stated that as the first priority of treatment, "-- all growing body cells be saturated with oxygen" and the second priority was to avoid further exposure to toxins.
Dr. Warburg's second priority to avoid further exposure to toxins is more difficult. We are exposed to toxins every day in the food we eat, water we drink and air we breathe. Every foreign invader that enters the body must be oxidized to pass through the body thus using valuable oxygen- oxygen needed for proper functioning. These unnatural substances include processed foods and preservatives (to extend life); food dyes; hydrogenated and partially hydrogenated foods; most vegetables oils (some rancid almost immediately); polluted water; chlorine, fluoride, lead, aluminum, etc. in water; polluted air (especially in the inner cities);smoking; excessive alcohol consumption; exercising to fatigue (moderate exercise is important); shallow breathing; pesticides; bleaching of napkins, toilet paper; etc. etc. etc.
Is it no wonder that most are oxygen depraved and diseases flourish.
It is therefore very important to supplement with oxygen daily. There are several oxygen supplements on market with more being introduced almost daily. This is the most important supplement you can take to avoid and reverse anaerobic diseases.
For information only, and should not be considered as medical advice. It is supplied so that you can make an informed decision.
Please consult with your health practitioner before considering any therapy or therapy protocol.
See: www.cellular-oxygenation.com
Herpes Cure Through Oxygenation
Herpes is a virus and viruses are anaerobic. They exist, survive and proliferate with little or no oxygen present. The herpes virus lacks the genetic material for reproduction and must inhabit a cell and rob the cell of its missing genetic material to multiply. They multiply by attaching themselves to DNA or RNA of normal cells forcing the cell to produce more of the virus. They remain latent until our defenses are down when they travel from cell to cell replicating wildly causing a herpes outbreak.
The herpes virus cannot exist in an elevated oxygen environment. Dr. Otto Warburg won the Nobel Prize for proving that viruses cannot proliferate, cannot exist in the presence of sufficient oxygen. This is a now an accepted fact. There has been many, many studies showing the destruction of viruses by the introduction of increased oxygenation whether it is in the form of ozone, hydrogen peroxide, hyperbaric oxygen, etc.
Cuba, Russia, West Germany and Italy have all successfully treated viral infections with increased oxygenation. At the Center of Medical and Surgical Research in Havana fifteen adults patients suffering from herpes zoster were treated with injections of ozone/oxygen for a period of fifteen days. All patients were completely symptom free after the treatment AND follow-up examinations a year later showed not one relapse.
Dr. R. Mattassi of the Division of Vascular Surgery at the Santa Corona Hospital in Milan, Italy treated 27 herpes patients with intravenous injections of oxygen and ozone. All patients healed completely after a minimum of one and a maximum of five injections. Five years later 24 of the 27 were still outbreak free. Re-infection was suspected in the other three.
Dr Parris Kidd has stated:
"Oxygen plays a pivotal role in the proper functioning of the immune system; i.e. resistance to disease, bacterial, and viruses."
Dr. Stephen Levine has also stated:
"We can look at oxygen deficiency as the single greatest cause of all disease."
Thus the development of a shortage of oxygen in the blood could very well be the starting point for the loss of the immune system and the beginning of feared health problems such as cancer, leukemia, AIDS, candida, seizures, and nerve deterioration.
Dr Freibott explains why oxygen and oxidation is so vital:
"It is the lack of oxygen in proper amounts in the system that prevents oxidation and oxygenation, which energizes the cells to biological regeneration. These processes are the foundation of life and death. If the normal environment of the cell can be maintained, it will not lose its growth and reproduction potential. Sub-oxygen creates sub-oxidation."
An oxygen deficiency plays an important part in cellular contamination. Oxygen is a powerful detoxifier, and when its quantity is deficient, toxins begin to devastate body functions and deplete the body of life-giving energy. Without oxygen, there can be no nourishment. Without nourishment, no heat and no energy can be created, and the body cannot purify itself. The unhindered development of this metabolic process results in a circumstance that we call sound health.
..........................................................................................................................................
Supply your body with Oxygen by introducing Sulfur back into your diet and eating proper foods. You have a choice and a responsibilty to take charge of your own health or you can continue on the same path and keep getting the same results.
Medication and drugs were never calculated to cure, only treat. Go after the cause and cure.
Medication, drugs, processed foods, smoking, excessive alcohol, chlorine, fluoride, etc. all deprive your body of the oxygen it needs to survive.
Ever wonder why over 200,000 people die each year from over medication or the wrong medication? Drug companies must sell drugs to keep the stock holders rich. Do they really care about your health?
Our bodies comprise 4% Sulfur but do not store or make Sulfur. We should be getting the Sulfur we need from the foods we eat, however, since 1954 the use of chemical fertilizers has apparently broken the Sulfur cycle.
Introduce Sulfur back into your diet and drink lots of pure water, which is oxygen, H20.
Sulfur is one main building block of life and the one element that carries oxygen to you cells.
For more information and to purchase the purest form of Organic Sulfur made in the USA from the Louisiana Marine Pine tree:
www.cellular-oxygenation.com
Disclaimer:
The information presented through this Web site is presented for educational purposes only. Because there is always some risk involved when changing diet and lifestyles, the author(s) and webmaster are not responsible for any adverse effects or consequences that might result. Please do not apply the techniques or the information on this web site if you are not willing to assume the risk. If you do use the information contained on this web site without the approval of a health professional, you are prescribing for yourself, which is your constitutional right, but the author(s) and webmaster assume no responsibility. The information presented through this Web site is not medical advice, and is not given as medical advice. Nor is it intended to propose or offer to propose a cure for any disease or condition. Before starting any medical treatment, please consult a physician.
CELLULAR-OXYGENATION.COM SHALL HAVE NO LIABILITY WHATSOEVER FOR DIRECT OR INDIRECT, SPECIAL OR CONSEQUENTIAL DAMAGES RELATING IN ANY WAY TO THE USE OF INFORMATION PROVIDED BY CELLULAR-OXYGENATION.COM OR ANY OF ITS RELATED WEB SITES, AUTHORS, SPONSORS, OR RESULTING FROM ANY DEFECTS OR FAILURE OF THIS INFORMATION.
This site contains links to other Internet sites. These links are not endorsements of any products or services in such sites, and no information in such site has been endorsed or approved by this site. Links are provided as Internet navigation tools only.
The people responsible for this web site are not medical professionals. We publish the information on this web site as a public service. While we hope the information presented here is helpful, what you do with it is your responsibility.
The Prime Cause of Cancer
In order to understand the dramatic effect of increased oxygenation on cancer (and all anaerobic diseases) it is important to explain the conditions (and the only conditions) which allow cancer cells to not only survive but multiply and flourish. In order to do this an explanation of the metabolism of healthy and unhealthy cells must be explained- or in this case non-cancerous and cancerous cells.
A normal healthy cell burns oxygen and glucose (blood sugar) for energy and releases carbon dioxide and. This healthy cell is functioning aerobically- in the presence of sufficient oxygen. No anaerobic (cancer, Epstein Barr, herpes, mono, genital warts, etc.) can flourish, replicate or even survive in this oxygen rich environment.
An unhealthy or diseased cell is lacking sufficient oxygen but will still produce energy by burning mainly. This is very inefficient and a severe drain on the body. This energy burning process (sugar fermentation) releases mainly lactic acid and carbon monoxide instead of carbon dioxide. This cell is functioning anaerobically- with no oxygen present. Cancer, viral diseases, etc. flourish in this environment-little or no oxygen (and low PH).
Anaerobic cells must work harder than aerobic cells to produce energy from the glucose they metabolize.
Therefore, anaerobic cells burn much more glucose to produce the same amount of energy as aerobic. Cancer cells exhibit this anaerobic mode of metabolism- lack of oxygen, high glucose consumption, carbon monoxide and high lactic acid production. Cancer cells thrive in this high sugar-low oxygen environment but cannot exist in the opposite condition of high oxygen-low sugar mode of healthy cells.
Dr. Otto Warburg, whose name has been bandied about so often that his significance has been unjustifiably minimized, was a biochemist in cancer research. He won the Nobel Prize in Medicine for proving that a cancer cell cannot exist in an oxidizing, healthy cell. Dr. Waburgh was the director of the Max Planck Institute for Cell Physiology in Germany. In "The Prime Cause and Prevention of Cancer" 1967,
Dr. Warburg proposed that normalizing the metabolism of cancer cells was the key to effective treatment cancer and the means to accomplish this was to increase the oxygen content of the cells. Dr.Warburg stated that as the first priority of treatment, "-- all growing body cells be saturated with oxygen" and the second priority was to avoid further exposure to toxins.
Dr. Warburg's second priority to avoid further exposure to toxins is more difficult. We are exposed to toxins every day in the food we eat, water we drink and air we breathe. Every foreign invader that enters the body must be oxidized to pass through the body thus using valuable oxygen- oxygen needed for proper functioning. These unnatural substances include processed foods and preservatives (to extend life); food dyes; hydrogenated and partially hydrogenated foods; most vegetables oils (some rancid almost immediately); polluted water; chlorine, fluoride, lead, aluminum, etc. in water; polluted air (especially in the inner cities);smoking; excessive alcohol consumption; exercising to fatigue (moderate exercise is important); shallow breathing; pesticides; bleaching of napkins, toilet paper; etc. etc. etc.
Is it no wonder that most are oxygen depraved and diseases flourish.
It is therefore very important to supplement with oxygen daily. There are several oxygen supplements on market with more being introduced almost daily. This is the most important supplement you can take to avoid and reverse anaerobic diseases.
For information only, and should not be considered as medical advice. It is supplied so that you can make an informed decision.
Please consult with your health practitioner before considering any therapy or therapy protocol.
See: www.cellular-oxygenation.com
Herpes Cure Through Oxygenation
Herpes is a virus and viruses are anaerobic. They exist, survive and proliferate with little or no oxygen present. The herpes virus lacks the genetic material for reproduction and must inhabit a cell and rob the cell of its missing genetic material to multiply. They multiply by attaching themselves to DNA or RNA of normal cells forcing the cell to produce more of the virus. They remain latent until our defenses are down when they travel from cell to cell replicating wildly causing a herpes outbreak.
The herpes virus cannot exist in an elevated oxygen environment. Dr. Otto Warburg won the Nobel Prize for proving that viruses cannot proliferate, cannot exist in the presence of sufficient oxygen. This is a now an accepted fact. There has been many, many studies showing the destruction of viruses by the introduction of increased oxygenation whether it is in the form of ozone, hydrogen peroxide, hyperbaric oxygen, etc.
Cuba, Russia, West Germany and Italy have all successfully treated viral infections with increased oxygenation. At the Center of Medical and Surgical Research in Havana fifteen adults patients suffering from herpes zoster were treated with injections of ozone/oxygen for a period of fifteen days. All patients were completely symptom free after the treatment AND follow-up examinations a year later showed not one relapse.
Dr. R. Mattassi of the Division of Vascular Surgery at the Santa Corona Hospital in Milan, Italy treated 27 herpes patients with intravenous injections of oxygen and ozone. All patients healed completely after a minimum of one and a maximum of five injections. Five years later 24 of the 27 were still outbreak free. Re-infection was suspected in the other three.
Dr Parris Kidd has stated:
"Oxygen plays a pivotal role in the proper functioning of the immune system; i.e. resistance to disease, bacterial, and viruses."
Dr. Stephen Levine has also stated:
"We can look at oxygen deficiency as the single greatest cause of all disease."
Thus the development of a shortage of oxygen in the blood could very well be the starting point for the loss of the immune system and the beginning of feared health problems such as cancer, leukemia, AIDS, candida, seizures, and nerve deterioration.
Dr Freibott explains why oxygen and oxidation is so vital:
"It is the lack of oxygen in proper amounts in the system that prevents oxidation and oxygenation, which energizes the cells to biological regeneration. These processes are the foundation of life and death. If the normal environment of the cell can be maintained, it will not lose its growth and reproduction potential. Sub-oxygen creates sub-oxidation."
An oxygen deficiency plays an important part in cellular contamination. Oxygen is a powerful detoxifier, and when its quantity is deficient, toxins begin to devastate body functions and deplete the body of life-giving energy. Without oxygen, there can be no nourishment. Without nourishment, no heat and no energy can be created, and the body cannot purify itself. The unhindered development of this metabolic process results in a circumstance that we call sound health.
..........................................................................................................................................
Supply your body with Oxygen by introducing Sulfur back into your diet and eating proper foods. You have a choice and a responsibilty to take charge of your own health or you can continue on the same path and keep getting the same results.
Medication and drugs were never calculated to cure, only treat. Go after the cause and cure.
Medication, drugs, processed foods, smoking, excessive alcohol, chlorine, fluoride, etc. all deprive your body of the oxygen it needs to survive.
Ever wonder why over 200,000 people die each year from over medication or the wrong medication? Drug companies must sell drugs to keep the stock holders rich. Do they really care about your health?
Our bodies comprise 4% Sulfur but do not store or make Sulfur. We should be getting the Sulfur we need from the foods we eat, however, since 1954 the use of chemical fertilizers has apparently broken the Sulfur cycle.
Introduce Sulfur back into your diet and drink lots of pure water, which is oxygen, H20.
Sulfur is one main building block of life and the one element that carries oxygen to you cells.
For more information and to purchase the purest form of Organic Sulfur made in the USA from the Louisiana Marine Pine tree:
www.cellular-oxygenation.com
Disclaimer:
The information presented through this Web site is presented for educational purposes only. Because there is always some risk involved when changing diet and lifestyles, the author(s) and webmaster are not responsible for any adverse effects or consequences that might result. Please do not apply the techniques or the information on this web site if you are not willing to assume the risk. If you do use the information contained on this web site without the approval of a health professional, you are prescribing for yourself, which is your constitutional right, but the author(s) and webmaster assume no responsibility. The information presented through this Web site is not medical advice, and is not given as medical advice. Nor is it intended to propose or offer to propose a cure for any disease or condition. Before starting any medical treatment, please consult a physician.
CELLULAR-OXYGENATION.COM SHALL HAVE NO LIABILITY WHATSOEVER FOR DIRECT OR INDIRECT, SPECIAL OR CONSEQUENTIAL DAMAGES RELATING IN ANY WAY TO THE USE OF INFORMATION PROVIDED BY CELLULAR-OXYGENATION.COM OR ANY OF ITS RELATED WEB SITES, AUTHORS, SPONSORS, OR RESULTING FROM ANY DEFECTS OR FAILURE OF THIS INFORMATION.
This site contains links to other Internet sites. These links are not endorsements of any products or services in such sites, and no information in such site has been endorsed or approved by this site. Links are provided as Internet navigation tools only.
The people responsible for this web site are not medical professionals. We publish the information on this web site as a public service. While we hope the information presented here is helpful, what you do with it is your responsibility.
Thursday, December 26, 2013
Sulfur is one of the few elements that transports oxygen right into your cells.
Fact: Bad bacteria cannot survive in an oxygen rich environment.
You can literally change your health with drinking enough clean water and supplementing with sulfur. Everything from the flora in your intestines to cell regeneration is affected by oxygen.
How much water? Take your weight. Divide by 2. Drink that number of ounces of water. So let’s say you are 180 pounds. Divide by 2 = 90. So 90 ounces of purified, chlorine-free water.
8 Facts about Sulfur you may not know:
1. Sulfur (chemical symbol S, atomic number 16) is one of the most important trace minerals on earth (around 5th most important) and is required for food production and a healthy body.
2. Sulfur is an essential element for all life.
3. Sulfur is required to regenerate our cells and if our body lacks Sulfur then our cells deteriorate and do not regenerate in a healthy manner, hence we become sick and illnesses such as cancer and heart problems occur.
4. Since 1954 chemical fertilizers were MANDATED by the US Government. Fertilizers containing ammonium nitrates and sulfates were used by farmers since being MANDATED, however, these fertilizers lack bioavailability and appear to have broken the Sulfur cycle in those countries that use these fertilizers.
5. Since 1954 the rate of disease in the US has increased by approximately 4,000% (percent) with a resultant decline in health, wealth, mental acuity and quality of life.
6. A study referred to as "The Sulfur Study" is expected to demonstrate a connection between the lack of Sulfur and the inability of cells to regenerate in a healthy manner. Final results are expected to be released very soon, but preliminary results highlight that all modern diseases can be attributed to mineral deficiencies.
7. Diseases that never seemed to exist in our Grandparents time now grow at an unprecedented rate and the quality of our food has been greatly diminished.
8. Our bodies comprise 4% Sulfur but do not store or make Sulfur. We should be getting the Sulfur we need from the foods we eat, however, since 1954 the use of chemical fertilizers has apparently broken the Sulfur cycle.
For more information and to purchase the purest form of Organic Sulfur made in the USA from the Louisiana Marine Pine tree:
Wednesday, December 25, 2013
Are you cells getting enough Oxygen?
The Oxygen View of Pain
THE OXYGEN VIEW OF PAIN:
EVERY CHRONIC PAIN IS SOME CELLS' CRY FOR OXYGEN
Majid Ali, M.D.
Oxygen is the organizing influence of human biology and governs the aging process. In 2000, I began Oxygen and Aging1 with those words. Oxygen is a master work of nature — an enduring tribute to Nature's preoccupation with complementarity and contrariety. It is an elixir of life and a hemlock for death — the ultimate molecular Dr. Jekyll and Mr. Hyde. Sometimes by its presence and sometimes by its absence, oxygen initiates signaling for cellular life as well as demise. In that context, it is important to recognize that oxygen drives chronic pain pathways primarily by its absence.
A large number of pain neurotransmitters are involved in clinical pain syndromes, including: substance P; enkephalins; neurokinin 1, 2, and 3; serotonin; adenosine triphosphate (ATP); nitric oxide; calcitonin; vasoactive intestinal peptides; epinephrine, norepinephrine, and related sympathomimetic agents; glutamic acid, aspartic acid, and related excitatory transmitters; and GABA, glycine, and related inhibitory transmitters.2-4 Some excitatory transmitters concerned with chronic pain include glutamic acid and aspartic acid, which are involved with dorsal horn sensitization through activation of NMDA receptors, while inhibitory transmitters participate in mechanisms that prevent or diminish pain. It seems safe to predict that future work will establish that, directly and indirectly, all those molecular species are triggered or influenced by oxygen deficit.
Oxygen and Pain Neurotransmitters
Neurotransmitters transmit information across synapses — regions separating neurons from adjoining neurons, as well as neurons from the muscle cells. These substances are stored in the bulbous ends of axons, and are released by electrical impulses traveling along the nerves to those ends. Upon their release, neurotransmitter either facilitate or inhibit continued electrical impulses along the nerve fibers on the other side of the synapse. Over 300 molecular species have been recognized to be involved in neurotransmission.5 Some of the best known of those over 300 neurotransmitters have been listed in a preceding section. It is regrettable that all neurologists and others in the headache industry I know limit their work only to serotonin and a few related neurotransmitters.
Next to oxygen and serotonin, substance P (SP) is the best examined of all the pain neurotransmitters, and its relationship with oxygen deficit has been most clearly delineated.6-11It is an 11-residue peptide belonging to the tachykinin sub-family of G-protein-coupled receptors (GPCR). Those receptors form a class of integral membrane proteins. Serotonin in the mammalian brain and receptors of the olfactory epithelium that binds odorants are two other members of this family are receptors.
Oxygen deficit triggers the release of substance P. There are several lines of direct and indirect evidence for it.12,13 Direct evidence for that comes from experiments in which decreasing concentrations of oxygen were associated with the release of increasing amounts of SP.12 Specifically, the carotid bodies contain SP — in concentrations ranging from 1.4 to 1.6 ng/mg protein — that is released in response to tissue hypoxia. The amount of SP released from the carotid bodies increases in proportion to the severity of hypoxia. It is noteworthy that the release of SP by hypoxia is a calcium-dependent process, and is primarily mediated by N- and L-type Ca2+ channels.13
Other lines of evidence for the fundamental role of oxygen deficit in the causation of pain include the following: (1) skin lactate levels are increased in complex regional pain14; (2) SP increases protein extravasation in regional chronic pain states15; (3) intradermal injection of epinephrine causes local pain (due to vasoconstriction and consequent oxygen deficit)16; (4) a tissue hypoxia occurs in complex regional pain syndrome17; (5) ascorbic acid reduces pain in reflex sympathetic dystrophy18; and (6) certain other free radial scavengers also reduce pain in complex regional pain states19 — the mechanism of action of antioxidants being restoration of local oxygen homeostasis.
Substance P exerts varied effects on different tissues.20-24 It is excitatory to the carotid body. Release of larger amounts of SP in the lungs is associated with pulmonary hypertension, an effect that is attenuated by antioxidants. In the nasal mucosa, hyperbaric oxygen decreases immunoreactivity to substance P.25 Not unexpectedly in light of the oxygen/SP dynamics, oxyradicals under certain conditions also trigger the release of substance P. By contrast, antioxidants, such as ascorbic acid, inhibit the release of SP.18 However, the relationships between antioxidants and SP are complex. For instance, ca
THE OXYGEN VIEW OF PAIN:
EVERY CHRONIC PAIN IS SOME CELLS' CRY FOR OXYGEN
Majid Ali, M.D.
Oxygen is the organizing influence of human biology and governs the aging process. In 2000, I began Oxygen and Aging1 with those words. Oxygen is a master work of nature — an enduring tribute to Nature's preoccupation with complementarity and contrariety. It is an elixir of life and a hemlock for death — the ultimate molecular Dr. Jekyll and Mr. Hyde. Sometimes by its presence and sometimes by its absence, oxygen initiates signaling for cellular life as well as demise. In that context, it is important to recognize that oxygen drives chronic pain pathways primarily by its absence.
A large number of pain neurotransmitters are involved in clinical pain syndromes, including: substance P; enkephalins; neurokinin 1, 2, and 3; serotonin; adenosine triphosphate (ATP); nitric oxide; calcitonin; vasoactive intestinal peptides; epinephrine, norepinephrine, and related sympathomimetic agents; glutamic acid, aspartic acid, and related excitatory transmitters; and GABA, glycine, and related inhibitory transmitters.2-4 Some excitatory transmitters concerned with chronic pain include glutamic acid and aspartic acid, which are involved with dorsal horn sensitization through activation of NMDA receptors, while inhibitory transmitters participate in mechanisms that prevent or diminish pain. It seems safe to predict that future work will establish that, directly and indirectly, all those molecular species are triggered or influenced by oxygen deficit.
Oxygen and Pain Neurotransmitters
Neurotransmitters transmit information across synapses — regions separating neurons from adjoining neurons, as well as neurons from the muscle cells. These substances are stored in the bulbous ends of axons, and are released by electrical impulses traveling along the nerves to those ends. Upon their release, neurotransmitter either facilitate or inhibit continued electrical impulses along the nerve fibers on the other side of the synapse. Over 300 molecular species have been recognized to be involved in neurotransmission.5 Some of the best known of those over 300 neurotransmitters have been listed in a preceding section. It is regrettable that all neurologists and others in the headache industry I know limit their work only to serotonin and a few related neurotransmitters.
Next to oxygen and serotonin, substance P (SP) is the best examined of all the pain neurotransmitters, and its relationship with oxygen deficit has been most clearly delineated.6-11It is an 11-residue peptide belonging to the tachykinin sub-family of G-protein-coupled receptors (GPCR). Those receptors form a class of integral membrane proteins. Serotonin in the mammalian brain and receptors of the olfactory epithelium that binds odorants are two other members of this family are receptors.
Oxygen deficit triggers the release of substance P. There are several lines of direct and indirect evidence for it.12,13 Direct evidence for that comes from experiments in which decreasing concentrations of oxygen were associated with the release of increasing amounts of SP.12 Specifically, the carotid bodies contain SP — in concentrations ranging from 1.4 to 1.6 ng/mg protein — that is released in response to tissue hypoxia. The amount of SP released from the carotid bodies increases in proportion to the severity of hypoxia. It is noteworthy that the release of SP by hypoxia is a calcium-dependent process, and is primarily mediated by N- and L-type Ca2+ channels.13
Other lines of evidence for the fundamental role of oxygen deficit in the causation of pain include the following: (1) skin lactate levels are increased in complex regional pain14; (2) SP increases protein extravasation in regional chronic pain states15; (3) intradermal injection of epinephrine causes local pain (due to vasoconstriction and consequent oxygen deficit)16; (4) a tissue hypoxia occurs in complex regional pain syndrome17; (5) ascorbic acid reduces pain in reflex sympathetic dystrophy18; and (6) certain other free radial scavengers also reduce pain in complex regional pain states19 — the mechanism of action of antioxidants being restoration of local oxygen homeostasis.
Substance P exerts varied effects on different tissues.20-24 It is excitatory to the carotid body. Release of larger amounts of SP in the lungs is associated with pulmonary hypertension, an effect that is attenuated by antioxidants. In the nasal mucosa, hyperbaric oxygen decreases immunoreactivity to substance P.25 Not unexpectedly in light of the oxygen/SP dynamics, oxyradicals under certain conditions also trigger the release of substance P. By contrast, antioxidants, such as ascorbic acid, inhibit the release of SP.18 However, the relationships between antioxidants and SP are complex. For instance, ca
icin increases
regional perfusion — and oxygen delivery, inhibiting the release of SP — but is
also known to increase SP release in the lung. Oxidants also have complex
relationships with SP. For example, nitric oxide serving as an oxidant modulates
histamine release from tissue mast cell and circulating basophils, and so
contributes to pain caused by histamine.26-27 On the other hand, nitric oxide,
through its vasodilator role, improves oxygen transport, decreases the release
of SP, and mitigates some pain syndromes. (See Nature's Preoccupation With
Complementarity and Contrariety, the first volume of The Principles and Practice
of Medicine,28 for an in-depth treatment of the subject).
Substance P also has complex relationships with certain other physiologic compounds, including enzymes and hormones.29,30 For instance, increased amounts of erythrocyte 2,3-diphosphoglycerate (2,3 DPG) caused by chronic hypoxia is associated with increased release of SP. Since chronic hypoxia increases the concentration of 2,3-DPG, this provides yet another mechanims by which oxygen deficit causes pain. Fascinating! How oxygen, by its absence, both triggers a mechanism for correcting that problem (by increasing 2,3-DGP production) and sends out messages to other cellular systems for participation in that effort (by inducing the production of SP). An example of the involvement of enzyme system with SP is that acute depressor actions of angiotensin II in the nucleus of the solitary tract are mediated by SP. An insight into the possible interactions between SP and hormones is provided by the complementary roles of SP and calcitonin gene-related peptide in the causation of phantom and ischemic pains.
An interesting aspect of the oxygen/substance P dynamics is revealed by the case of the East African naked mole-rats (Heterocephalus glaber). This rat species lacks substance P and does not appear to suffer pain when tormented.31 The rats feel no immediate pain when cut, scraped or subjected to heat stimuli. They only feel some aches. But when the rats get a shot of SP, pain signaling resumes working as in other mammals. One can only wonder about what other defense mechanisms exist in this rat species that compensate for substance P.
On the Nature of Pain
Pain is a sensory perception intricately linked to the emotional state of the person. Pain is not a disease, nor a discrete bodily state. That explains why pain in different cultures means different things to different people. This is a crucially important aspect of pain when considering the biochemistry of pain neurotransmitters presented above. I had certain ideas of pain during three decades of my work as a surgeon and a pathologist. In those years, I suffered migraine attacks. Since vomiting accompanying migraine did not allow me to keep any painkillers down, I gave myself Demerol injection for relief. My work in integrative medicine changed all that. Then I taught myself control of migraine by assuring optimal hydration, preventing rapid hypoglycemic/hyperglycemic roller coasters and consequent rapid insulin shifts, addressing issues of mold and food allergy, and controlling vasospasm with self-regulatory methods — all measures that restore oxygen homeostasis, locally or systemically. I have not had to take Demerol during the last eight years. I have a prolapsed lumbar disc which sometimes caused disabling backache. During those years, I also taught myself control of that pain with Limbic Breathing32 — an energetic method of breathing with extended periods of exhalation (see Healing Miracles and the Bite of the Gray Dog33 for details of other effective self-regulatory methods). For years, I have controlled my back pain with limbic breathing, without any painkillers, manipulations, laser or other therapies.
I might point out here that direct oxygen therapies — oxygen by mask and hyperbaric oxygen — have been successfully used in controlling headaches and migraine attacks.34-37 Specifically, in one double-blind trial breathing 100% oxygen for 15 minutes or less during headache episodes controlled or significantly reduced the pain of acute cluster attacks in all subjects.34 Not surprisingly, one fourth of the study participants experienced cluster attacks soon after the treatment was stopped35 — since various elements putting in jeopardy oxygen homeostasis were not addressed. Administration of higher concentrations of oxygen during the postoperative period relieves or reduces the intensity of postoperative pain. It appears to both reduce the release of substance P and influence pain inhibitory pathways in the peripheral nerves. Correlation between urinary substance P and bladder pain has been documented.
Seeing Pain, Thinking Oxygen
In my clinical work when I see pain, I think oxygen. I think about how dehydration in one person worsens functional oxygen deficits, and how incremental oxidative stress threatens oxygen homeostasis — locally and/or systemically — in another. I think about how hyperglycemic- hypoglycemic shifts trigger rapid insulin responses increases the intensity of pain in yet others. I think about how undetected and unmanaged allergic triggers acting in the bowel and elsewhere cumulatively cause oxidosis, acidosis, dehydration, add to oxidosis, acidosis — and then all collectively threaten functionality of oxygen, increasing the degree of pain regardless what the initial pain triggers might be. Then I wonder how often do neurologists and anesthesiologists at pain centers think about the effects of total body burden of toxic metals and xenobiotics on pain neurochemistry — by feeding the frenzy of the three furies of pain — oxidosis, acidosis, and dysoxygenosis.
Following are some commonly observed clinical manifestations of biochemical interactions among the pain sensors and modifiers listed above:
1. Coronary chest pain is relieved or mitigated by the administration of oxygen, as are attacks of headache and migraine34-37;
2. Direct oxystatic measures — treatments that restore oxygen homeostasis, including ozone, hydrogen peroxide, singlet oxygen, and related treatments — prevent, diminish or relieve diffuse tissue pain in fibromyalgia38,39;
3. Indirect oxystatic measures — treatments such as prolotherapy with injection of 50% glucose or other suitable agents that stimulate fibroproliferative responses — relieve trigger point pain by evoking local oxystatic inflammatory tissue response40;
5. Chronic back pain in many cases can be relieved by effective self-regulatory methods, especially with specific breathing methods (see limbic breathing in The Cortical Monkey and Healing32;
6. Pain syndromes accompanying reflex sympathetic dystrophy can be relieved with direct oxystatic therapies combined with indirect oxystatic measures, including restoration of bowel ecology and hepatic detoxification (personal unpublished observations); and
7. Cooling of forehead diminishes sympathetic tone, increases regional blood supply (correcting oxygen deficit), and relieves certain types of pain associated with dysautonomia.41
On deeper reflection, the pain-relieving roles of oxygen and oxyradicals can be recognized in most, if not all, empirically proven pain control therapies. Indeed, in my own clinical work I find that every chronic pain can be partially or completely controlled by effective direct and indirect oxystatic therapies. That, in essence, is the "oxygen view of pain" presented in this article.
Author's Priorities for Headache and Migraine: A Clinical Application of the Oxygen View of Pain
Headache and migraine patients must take the time to understand the true nature of their suffering, and not waste time on worrying what type of headache and migraine they may or may not have. They must understand that drug therapies cannot be accepted as the full treatment of their suffering. They must know that their suffering can be prevented by non-drug therapies, except in rare instances of pain associated with depression, anxiety, or drug dependence. It is mandatory to have tests done for antibodies for molds and this issue addressed. Mold sensitivity was present in nearly all of my patients with headache attacks. The same holds for uncovering and effectively managing food sensitivities. Even ordinary fluctuations in blood sugar levels can trigger headache attacks. So headache and migraine patients must not miss breakfast. Similarly, dehydration increases vulnerability to headache, and optimal hydration must be assured for optimal control of headache. In many instances, myofascial trigger points in the neck, shoulders, and scalp trigger headache attacks. Such trigger points require resolution by appropriate therapies. The author's choice is prolotherapy with 50% glucose.40 Headache and migraine patients must become sensitive to problems caused by excess acidity.
Cellular oxidosis, acidosis, and dysoxygenosis resulting from nutrient deficits can trigger, perpetuate, or intensify headache. So, I consider nutritional therapies — magnesium, calcium, and potassium stand out in this context — as well as selected phytotherapies as important components of the program. And most importantly, headache and migraine attacks are commonly triggered by stress and perpetuated by chronic anger. Thus, such patients must learn effective self-regulatory methods for prevention and treatment of headache. (See Healing Miracles and the Bite of the Gray Dog.23) Most importantly, persons with headache and migraine must learn to think oxygen when they experience pain. They need to recognize that self- regulatory, nutritional, and environmental measures enlighten and empower them, while drug therapies for headache disempower the sufferers and keep them in the dark.
In closing, the crucial clinical importance of the "oxygen view of pain" presented above is this: It mandates that all relevant oxygen issues be diligently addressed in the clinical management of every patient with a chronic pain syndrome. How often do clinicians recognize the essential commonality of biochemical lesions — oxidosis, acidosis, and dysoxygenosis — that cause migraine and heart attack? How often do they see that commonality between the pain episodes of severe dysmenorrhea and myofascial trigger points? And that between arthritis and sympathetic reflex dystrophy? And that between pain of prolapsed vertebral discs and fibromyalgia? And that between pain of TMJ and renal colic? The oxygen view of pain provides a clear link. What might be required for managing ischemic coronary syndromes with the oxygen view of pain? The same approach as for controlling migraine attacks given above. Why? Because the oxygen issues that cause oxidative coagulopathy and so set the stage for coronary artery blockages are exactly the same as those that trigger migraine attacks. Cholesterol, I might add here, is an antioxidant and protects the coronary arteries until it gets oxidized, becomes rancid, contributes to oxidative coagulopathy, and sets the stage for atherosclerosis.
References
1. Ali M. Oxygen and Aging. (Ist ed.) 2000. New York, Canary 21 Press. Aging Healthfully Book 2000.
2. Darnell J, Lodish H, Baltimore D. Molecular Cell Biology. 1990. New York. Scientific American Books. Distribted by WH Freeman and Company. pp 784-802.
3. Katz B. Nerve, Muscle, and Synapse. 2nd. ed. 1966. New York. McGraw-Hill.
4. Salerno, Evelyn, and Joyce S. Willens, eds. Pain Management Handbook: An Interdisciplinary Approach. St. Louis: Mosby, 1996.
5. Verbunt J, Seelen H, Vlaeyen J, et al. Disuse and deconditioning in chronic low back pain: concepts and hypotheses on contributing mechanisms. Eur J Pain 2003;7:9-21.
6. Krause JE, Takeda Y, Hershey AD. Structure, functions, and mechanisms of substance p receptor action. J Invest Dermatol. 1992;98:2S-7S.
7. Pernow B. Substance P. Pharmacol Rev. 1983;35:85-141.
8. Bolton TB, Clapp LH. Endothelial-dependent relaxant actions of carbachol and substance p in arterial smooth muscle. Br J Pharmacol. 1986;87:713-723.
9. Diz DI, Fantz DL, Benter IF, Bosch SM. Acute depressor actions of angiotensin II in the nucleus of the solitary tract are mediated by substance P. Am J Physiol. 1997;273:R28-R34.
10. Tagawa T, Mohri M, Tagawa H, Egashira K, Shimokawa H, Kuga T, Hirooka Y, Takeshita A. Role of nitric oxide in substance p-induced vasodilation differs between the coronary and forearm circulations in humans. J Cardiovasc Pharmacol. 1997;29:546 -553.
11. Naoko Kanda and Shinichi Watanabe . Substance P Enhances the Production of Interferon-induced Protein of 10 kDa by Human Keratinocytes in Synergy with Interferon- Journal of Investigative Dermatology 119, 1290-1297 (2002)
12. Kim DK, Oh EK, Summers BA, Prabhakar NR, Kumar GK. Release of substance P by low oxygen in the rabbit carotid body: evidence for the involvement of calcium channels. Brain Res. 2001 Feb 23;892(2):359-69.
13. Chen MJ, Chiang LY, Lai YL. Reactive oxygen species and substance P in monocrotaline-induced pulmonary hypertension. 1: Toxicol Appl Pharmacol. 2001;171:165-73.
14. Birklein F, Weber M, Neundorfer B. Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia? Neurology. 2000;55:1213-5.
15. Leis S,WeberM, Isselmann A, SchmelzM, Birklein F. Substance-P-induced protein extravasation is bilaterally increased in complex regional pain syndrome. Exp Neurol 2003;183:197-204.
16. Ali Z, Raja S, Wesselmann U, et al. Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain. Pain 2000;88:161-8.
17. Koban M, Leis S, Schultze-Mosgau S, et al. Tissue hypoxia in complex regional pain syndrome. Pain 2003;104:149-57.
18. Zollinger P, Tuinebreijer W, Kreis R, et al. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet 1999;354:2025-8.
19. Perez R, Zuurmond W, Bezemer P, et al. The treatment of complex regional pain syndrome type I with free radical scavengers: a randomized controlled study. Pain 2003;102:297-307.
20. Noguchi K et al: Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons. J Neurosci. 1995;15:7633.
21. Milan P Stojanovic M. Stimulation Methods for Neuropathic Pain Contro. Current Pain and Headache Reports 2001, 5:130-137. // MGH Pain Center Department of Anesthesia and Critical Care, 15 Parkman Street, Massachusetts General Hospital, Boston, MA, 02114, USA // Current Pain and Headache Reports 2001, 5:130-137.
22. Ochoa J, Verdugo R. Mechanisms of neuropathic pain: nerve, brain, and psyche: perhaps the dorsal horn but not the sympathetic system. Clin Auton Res 2001;11:335-9.
23. Sicuteri F, Fanciullacci M, Nicolodi M, et al. Substance P theory: a unique focus on the painful and painless phenomena of cluster headache. Headache 1990;30:69-79.
24. Lynn B. Capsaicin. Actions on nociceptive C-fibers and therapeutic potential. Pain 1990;41:61-9.
25. DiSabato F, Giacovazzo M, Cristalli G, et al. Effect of hyperbaric oxygen on the immunoreactivity to substance P in the nasal mucosa of cluster headache patients. Headache 1996;36:221-3.
26. A. C. Brooks*,1, C. J. Whelan1 and W. M. Purcell2. Reactive oxygen species generation and histamine release by activated mast cells: modulation by nitric oxide synthase inhibition. British Journal of Pharmacology 128:585-590 (1999)
27. Fusco BM, Fiore G, Gallo F, et al. "Capsaicin-sensitive" sensory neurons in cluster headache: pathophysiological aspects and therapeutic indication. Headache 1994;34:132-7.
28. Ali M. Nature's Preoccupation With Complementarity and Contrariety, The Principles and Practice of Integrative Medicine Volume II. 2001. Washington, D.C. Capital University Press (in collaboration with Canary 21 Press, New York). www.cuim.edu & www.Canary21press.com)
29. Baynes J, Dominiczak MH. Medical Biochemistry. 1999. New York. Mosby. pp31-39.
30. Pascual J, Peralta G, Sanchez U. Preventive effects of hyperbaric oxygen in cluster headache. Headache 1995;35:260-1.
31. Mendizabal JE, Umana E, Zweifler RM. Cluster Headache: Horton's Cephalalgia Revisited. South Med J 1998;91:606-17 [review].
32. Ali M. The Cortical Monkey and Healing. 1991. Bloomfield, New Jersey. Life Span Books 1991.
33. Ali M. Miracles, and the Bite of the Gray Dog, 1997. Denville, New Jersey, Life Span Books.
34. Fogan L. Treatment of cluster headache. A double-blind comparison of oxygen v air inhalation. Arch Neurol 1985;43:362-3.
35. Kudrow L. Response of cluster headache attacks to oxygen inhalation. Headache 1981;21:1-4.
36. H eterocephalus glaber. www.sciencedaily.com/releases/2003/11/031117073925.htm
37. DiSabato F, Fusco BM, Pelaia P, Giacovazzo M. Hyperbaric oxygen therapy in cluster headache. Pain 1993;52:243-5.
38 Ali M: Fibromyalgia: an oxidative-dysoxygenative disorder (ODD). J Integrative Medicine 1999; 3:17-37.
39. Ali M: Darwin, fatigue, and fibromyalgia. J Integrative Medicine 1999;3:5-10.
40. Ali M: ODD trigger points in fibromyalgia: pathogenesis, diagnosis, and resolution J Integrative Med 1999; 3:38-47.
41. Stanton-Hicks M, Janig W, Hassenbusch S, et al. Reflex sympathetic dystrophy: changing concepts and taxonomy. Pain. 1995;63:127-33. Also: Drummond P D. Involvement of the sympathetic nervous system in complex regional pain syndrome. ijl.sagepub.com/cgi//reprint.
Substance P also has complex relationships with certain other physiologic compounds, including enzymes and hormones.29,30 For instance, increased amounts of erythrocyte 2,3-diphosphoglycerate (2,3 DPG) caused by chronic hypoxia is associated with increased release of SP. Since chronic hypoxia increases the concentration of 2,3-DPG, this provides yet another mechanims by which oxygen deficit causes pain. Fascinating! How oxygen, by its absence, both triggers a mechanism for correcting that problem (by increasing 2,3-DGP production) and sends out messages to other cellular systems for participation in that effort (by inducing the production of SP). An example of the involvement of enzyme system with SP is that acute depressor actions of angiotensin II in the nucleus of the solitary tract are mediated by SP. An insight into the possible interactions between SP and hormones is provided by the complementary roles of SP and calcitonin gene-related peptide in the causation of phantom and ischemic pains.
An interesting aspect of the oxygen/substance P dynamics is revealed by the case of the East African naked mole-rats (Heterocephalus glaber). This rat species lacks substance P and does not appear to suffer pain when tormented.31 The rats feel no immediate pain when cut, scraped or subjected to heat stimuli. They only feel some aches. But when the rats get a shot of SP, pain signaling resumes working as in other mammals. One can only wonder about what other defense mechanisms exist in this rat species that compensate for substance P.
On the Nature of Pain
Pain is a sensory perception intricately linked to the emotional state of the person. Pain is not a disease, nor a discrete bodily state. That explains why pain in different cultures means different things to different people. This is a crucially important aspect of pain when considering the biochemistry of pain neurotransmitters presented above. I had certain ideas of pain during three decades of my work as a surgeon and a pathologist. In those years, I suffered migraine attacks. Since vomiting accompanying migraine did not allow me to keep any painkillers down, I gave myself Demerol injection for relief. My work in integrative medicine changed all that. Then I taught myself control of migraine by assuring optimal hydration, preventing rapid hypoglycemic/hyperglycemic roller coasters and consequent rapid insulin shifts, addressing issues of mold and food allergy, and controlling vasospasm with self-regulatory methods — all measures that restore oxygen homeostasis, locally or systemically. I have not had to take Demerol during the last eight years. I have a prolapsed lumbar disc which sometimes caused disabling backache. During those years, I also taught myself control of that pain with Limbic Breathing32 — an energetic method of breathing with extended periods of exhalation (see Healing Miracles and the Bite of the Gray Dog33 for details of other effective self-regulatory methods). For years, I have controlled my back pain with limbic breathing, without any painkillers, manipulations, laser or other therapies.
I might point out here that direct oxygen therapies — oxygen by mask and hyperbaric oxygen — have been successfully used in controlling headaches and migraine attacks.34-37 Specifically, in one double-blind trial breathing 100% oxygen for 15 minutes or less during headache episodes controlled or significantly reduced the pain of acute cluster attacks in all subjects.34 Not surprisingly, one fourth of the study participants experienced cluster attacks soon after the treatment was stopped35 — since various elements putting in jeopardy oxygen homeostasis were not addressed. Administration of higher concentrations of oxygen during the postoperative period relieves or reduces the intensity of postoperative pain. It appears to both reduce the release of substance P and influence pain inhibitory pathways in the peripheral nerves. Correlation between urinary substance P and bladder pain has been documented.
Seeing Pain, Thinking Oxygen
In my clinical work when I see pain, I think oxygen. I think about how dehydration in one person worsens functional oxygen deficits, and how incremental oxidative stress threatens oxygen homeostasis — locally and/or systemically — in another. I think about how hyperglycemic- hypoglycemic shifts trigger rapid insulin responses increases the intensity of pain in yet others. I think about how undetected and unmanaged allergic triggers acting in the bowel and elsewhere cumulatively cause oxidosis, acidosis, dehydration, add to oxidosis, acidosis — and then all collectively threaten functionality of oxygen, increasing the degree of pain regardless what the initial pain triggers might be. Then I wonder how often do neurologists and anesthesiologists at pain centers think about the effects of total body burden of toxic metals and xenobiotics on pain neurochemistry — by feeding the frenzy of the three furies of pain — oxidosis, acidosis, and dysoxygenosis.
Following are some commonly observed clinical manifestations of biochemical interactions among the pain sensors and modifiers listed above:
1. Coronary chest pain is relieved or mitigated by the administration of oxygen, as are attacks of headache and migraine34-37;
2. Direct oxystatic measures — treatments that restore oxygen homeostasis, including ozone, hydrogen peroxide, singlet oxygen, and related treatments — prevent, diminish or relieve diffuse tissue pain in fibromyalgia38,39;
3. Indirect oxystatic measures — treatments such as prolotherapy with injection of 50% glucose or other suitable agents that stimulate fibroproliferative responses — relieve trigger point pain by evoking local oxystatic inflammatory tissue response40;
5. Chronic back pain in many cases can be relieved by effective self-regulatory methods, especially with specific breathing methods (see limbic breathing in The Cortical Monkey and Healing32;
6. Pain syndromes accompanying reflex sympathetic dystrophy can be relieved with direct oxystatic therapies combined with indirect oxystatic measures, including restoration of bowel ecology and hepatic detoxification (personal unpublished observations); and
7. Cooling of forehead diminishes sympathetic tone, increases regional blood supply (correcting oxygen deficit), and relieves certain types of pain associated with dysautonomia.41
On deeper reflection, the pain-relieving roles of oxygen and oxyradicals can be recognized in most, if not all, empirically proven pain control therapies. Indeed, in my own clinical work I find that every chronic pain can be partially or completely controlled by effective direct and indirect oxystatic therapies. That, in essence, is the "oxygen view of pain" presented in this article.
Author's Priorities for Headache and Migraine: A Clinical Application of the Oxygen View of Pain
Headache and migraine patients must take the time to understand the true nature of their suffering, and not waste time on worrying what type of headache and migraine they may or may not have. They must understand that drug therapies cannot be accepted as the full treatment of their suffering. They must know that their suffering can be prevented by non-drug therapies, except in rare instances of pain associated with depression, anxiety, or drug dependence. It is mandatory to have tests done for antibodies for molds and this issue addressed. Mold sensitivity was present in nearly all of my patients with headache attacks. The same holds for uncovering and effectively managing food sensitivities. Even ordinary fluctuations in blood sugar levels can trigger headache attacks. So headache and migraine patients must not miss breakfast. Similarly, dehydration increases vulnerability to headache, and optimal hydration must be assured for optimal control of headache. In many instances, myofascial trigger points in the neck, shoulders, and scalp trigger headache attacks. Such trigger points require resolution by appropriate therapies. The author's choice is prolotherapy with 50% glucose.40 Headache and migraine patients must become sensitive to problems caused by excess acidity.
Cellular oxidosis, acidosis, and dysoxygenosis resulting from nutrient deficits can trigger, perpetuate, or intensify headache. So, I consider nutritional therapies — magnesium, calcium, and potassium stand out in this context — as well as selected phytotherapies as important components of the program. And most importantly, headache and migraine attacks are commonly triggered by stress and perpetuated by chronic anger. Thus, such patients must learn effective self-regulatory methods for prevention and treatment of headache. (See Healing Miracles and the Bite of the Gray Dog.23) Most importantly, persons with headache and migraine must learn to think oxygen when they experience pain. They need to recognize that self- regulatory, nutritional, and environmental measures enlighten and empower them, while drug therapies for headache disempower the sufferers and keep them in the dark.
In closing, the crucial clinical importance of the "oxygen view of pain" presented above is this: It mandates that all relevant oxygen issues be diligently addressed in the clinical management of every patient with a chronic pain syndrome. How often do clinicians recognize the essential commonality of biochemical lesions — oxidosis, acidosis, and dysoxygenosis — that cause migraine and heart attack? How often do they see that commonality between the pain episodes of severe dysmenorrhea and myofascial trigger points? And that between arthritis and sympathetic reflex dystrophy? And that between pain of prolapsed vertebral discs and fibromyalgia? And that between pain of TMJ and renal colic? The oxygen view of pain provides a clear link. What might be required for managing ischemic coronary syndromes with the oxygen view of pain? The same approach as for controlling migraine attacks given above. Why? Because the oxygen issues that cause oxidative coagulopathy and so set the stage for coronary artery blockages are exactly the same as those that trigger migraine attacks. Cholesterol, I might add here, is an antioxidant and protects the coronary arteries until it gets oxidized, becomes rancid, contributes to oxidative coagulopathy, and sets the stage for atherosclerosis.
References
1. Ali M. Oxygen and Aging. (Ist ed.) 2000. New York, Canary 21 Press. Aging Healthfully Book 2000.
2. Darnell J, Lodish H, Baltimore D. Molecular Cell Biology. 1990. New York. Scientific American Books. Distribted by WH Freeman and Company. pp 784-802.
3. Katz B. Nerve, Muscle, and Synapse. 2nd. ed. 1966. New York. McGraw-Hill.
4. Salerno, Evelyn, and Joyce S. Willens, eds. Pain Management Handbook: An Interdisciplinary Approach. St. Louis: Mosby, 1996.
5. Verbunt J, Seelen H, Vlaeyen J, et al. Disuse and deconditioning in chronic low back pain: concepts and hypotheses on contributing mechanisms. Eur J Pain 2003;7:9-21.
6. Krause JE, Takeda Y, Hershey AD. Structure, functions, and mechanisms of substance p receptor action. J Invest Dermatol. 1992;98:2S-7S.
7. Pernow B. Substance P. Pharmacol Rev. 1983;35:85-141.
8. Bolton TB, Clapp LH. Endothelial-dependent relaxant actions of carbachol and substance p in arterial smooth muscle. Br J Pharmacol. 1986;87:713-723.
9. Diz DI, Fantz DL, Benter IF, Bosch SM. Acute depressor actions of angiotensin II in the nucleus of the solitary tract are mediated by substance P. Am J Physiol. 1997;273:R28-R34.
10. Tagawa T, Mohri M, Tagawa H, Egashira K, Shimokawa H, Kuga T, Hirooka Y, Takeshita A. Role of nitric oxide in substance p-induced vasodilation differs between the coronary and forearm circulations in humans. J Cardiovasc Pharmacol. 1997;29:546 -553.
11. Naoko Kanda and Shinichi Watanabe . Substance P Enhances the Production of Interferon-induced Protein of 10 kDa by Human Keratinocytes in Synergy with Interferon- Journal of Investigative Dermatology 119, 1290-1297 (2002)
12. Kim DK, Oh EK, Summers BA, Prabhakar NR, Kumar GK. Release of substance P by low oxygen in the rabbit carotid body: evidence for the involvement of calcium channels. Brain Res. 2001 Feb 23;892(2):359-69.
13. Chen MJ, Chiang LY, Lai YL. Reactive oxygen species and substance P in monocrotaline-induced pulmonary hypertension. 1: Toxicol Appl Pharmacol. 2001;171:165-73.
14. Birklein F, Weber M, Neundorfer B. Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia? Neurology. 2000;55:1213-5.
15. Leis S,WeberM, Isselmann A, SchmelzM, Birklein F. Substance-P-induced protein extravasation is bilaterally increased in complex regional pain syndrome. Exp Neurol 2003;183:197-204.
16. Ali Z, Raja S, Wesselmann U, et al. Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain. Pain 2000;88:161-8.
17. Koban M, Leis S, Schultze-Mosgau S, et al. Tissue hypoxia in complex regional pain syndrome. Pain 2003;104:149-57.
18. Zollinger P, Tuinebreijer W, Kreis R, et al. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet 1999;354:2025-8.
19. Perez R, Zuurmond W, Bezemer P, et al. The treatment of complex regional pain syndrome type I with free radical scavengers: a randomized controlled study. Pain 2003;102:297-307.
20. Noguchi K et al: Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons. J Neurosci. 1995;15:7633.
21. Milan P Stojanovic M. Stimulation Methods for Neuropathic Pain Contro. Current Pain and Headache Reports 2001, 5:130-137. // MGH Pain Center Department of Anesthesia and Critical Care, 15 Parkman Street, Massachusetts General Hospital, Boston, MA, 02114, USA // Current Pain and Headache Reports 2001, 5:130-137.
22. Ochoa J, Verdugo R. Mechanisms of neuropathic pain: nerve, brain, and psyche: perhaps the dorsal horn but not the sympathetic system. Clin Auton Res 2001;11:335-9.
23. Sicuteri F, Fanciullacci M, Nicolodi M, et al. Substance P theory: a unique focus on the painful and painless phenomena of cluster headache. Headache 1990;30:69-79.
24. Lynn B. Capsaicin. Actions on nociceptive C-fibers and therapeutic potential. Pain 1990;41:61-9.
25. DiSabato F, Giacovazzo M, Cristalli G, et al. Effect of hyperbaric oxygen on the immunoreactivity to substance P in the nasal mucosa of cluster headache patients. Headache 1996;36:221-3.
26. A. C. Brooks*,1, C. J. Whelan1 and W. M. Purcell2. Reactive oxygen species generation and histamine release by activated mast cells: modulation by nitric oxide synthase inhibition. British Journal of Pharmacology 128:585-590 (1999)
27. Fusco BM, Fiore G, Gallo F, et al. "Capsaicin-sensitive" sensory neurons in cluster headache: pathophysiological aspects and therapeutic indication. Headache 1994;34:132-7.
28. Ali M. Nature's Preoccupation With Complementarity and Contrariety, The Principles and Practice of Integrative Medicine Volume II. 2001. Washington, D.C. Capital University Press (in collaboration with Canary 21 Press, New York). www.cuim.edu & www.Canary21press.com)
29. Baynes J, Dominiczak MH. Medical Biochemistry. 1999. New York. Mosby. pp31-39.
30. Pascual J, Peralta G, Sanchez U. Preventive effects of hyperbaric oxygen in cluster headache. Headache 1995;35:260-1.
31. Mendizabal JE, Umana E, Zweifler RM. Cluster Headache: Horton's Cephalalgia Revisited. South Med J 1998;91:606-17 [review].
32. Ali M. The Cortical Monkey and Healing. 1991. Bloomfield, New Jersey. Life Span Books 1991.
33. Ali M. Miracles, and the Bite of the Gray Dog, 1997. Denville, New Jersey, Life Span Books.
34. Fogan L. Treatment of cluster headache. A double-blind comparison of oxygen v air inhalation. Arch Neurol 1985;43:362-3.
35. Kudrow L. Response of cluster headache attacks to oxygen inhalation. Headache 1981;21:1-4.
36. H eterocephalus glaber. www.sciencedaily.com/releases/2003/11/031117073925.htm
37. DiSabato F, Fusco BM, Pelaia P, Giacovazzo M. Hyperbaric oxygen therapy in cluster headache. Pain 1993;52:243-5.
38 Ali M: Fibromyalgia: an oxidative-dysoxygenative disorder (ODD). J Integrative Medicine 1999; 3:17-37.
39. Ali M: Darwin, fatigue, and fibromyalgia. J Integrative Medicine 1999;3:5-10.
40. Ali M: ODD trigger points in fibromyalgia: pathogenesis, diagnosis, and resolution J Integrative Med 1999; 3:38-47.
41. Stanton-Hicks M, Janig W, Hassenbusch S, et al. Reflex sympathetic dystrophy: changing concepts and taxonomy. Pain. 1995;63:127-33. Also: Drummond P D. Involvement of the sympathetic nervous system in complex regional pain syndrome. ijl.sagepub.com/cgi//reprint.
Flood you body with Oxygen: http://cellular-oxygenation.com/
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not intended to diagnose, cure, treat, or prevent any disease. The
information presented through this Web site, Cellular-oxygenation.com, is not medical advice, and
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