Chronic cellular hypoxia as the prime cause of cancer: what is the de-oxygenating role of adulterated and improper ratios of polyunsaturated fatty acids when incorporated into cell membranes?
Abstract
With
the exception of melanoma and non-Hodgkin's lymphoma, the incidence of
cancer has peaked in the last several years, but rates and mortality are
still high. Moreover, despite 50 years of intensive cancer research
increasingly focused on genetic causes, no single unifying cause for
cancer has been established. Although it is well-known that tumors are
hypoxic, and that there is a correlation between the level of hypoxia
and prognosis, with the exception of Warburg's studies, little work has
been done to investigate the relationship between hypoxia and cancer.
Over 70 years ago, Warburg showed that cells could always be made
cancerous by subjecting them to periods of hypoxia. Moreover, he
demonstrated that once cells had converted to a cancerous state,
reversion could not occur. Modern biochemistry acknowledges that there
is a switch from oxidative phosphorylation to glycolysis in tumors that
might be concurrent with hypoxia, but does not address the cancer
causation. It is our hypothesis that long-term hypoxia of cells in the
body, measured in years, is the primary trigger for cancer. We believe
that the hypoxia, which has to meet Warburg's findings of a critical 35%
reduction in intracellular oxygen levels to initiate cancer, is linked
to the incorporation of adulterated, non-oxygenating, or inappropriate
polyunsaturated fatty acids (PUFAs) into the phospholipids of cell and
mitochondrial membranes. Such incorporation causes changes in membrane
properties that impair oxygen transmission into the cell. Trans fats,
partially oxidized PUFA entities, and inappropriate omega-6:omega-3
ratios are all potential sources of unsaturated fatty acids that can
disrupt the normal membrane structure. In this paper, we explore this
hypothesis by examining the evidence, and additionally propose an
appropriate PUFA dosage for humans by analyzing requirements and taking
into account current PUFA consumption patterns.
- PMID:
- 17656037
- [PubMed - indexed for MEDLINE]
- Hypoxia (also known as hypoxiation) is a condition in which the body or a region of the body is deprived of adequate oxygen supply.
- Supply your body with Pure Organic Sulfur, which is the element that transfers oxygen to the cells. It is also one of the major building blocks of life and without you will not survive. Unfortunately during the 1950's with the introduction of Chemical fertilizers we lack the proper amount of Sulfur our bodies need to fight off cancer and other illnesses.
- *These statements have not been evaluated by the FDA. This product is not intended to diagnose, cure, treat, or prevent any disease. The information presented through this Web site is not medical advice, and is not given as medical advice. Nor is it intended to propose or offer to propose a cure for any disease or condition. Before starting any medical treatment, please consult a physician.
TO ORDER Click on the website link:
No comments:
Post a Comment